Custom Peptides
Cayman Chemical R-PFI-2hydrochlorIde 10mg
A potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases
Cayman Chemical 11-Hydroxyprogesteron 10mg
A metabolite of progesterone; an MR agonist (EC50 = 0.05 µM in a reporter assay); an inhibitor of 11β-HSD2 and 11β-HSD1 (IC50s = 0.140 and 1 µM, respectively); increases blood pressure in rats at 10 UG/hour; serum levels are increased in patients with 21-hydroxylase deficiency
Cayman Chemical CevImelInhydrochlorIde 10mg
A muscarinic receptor agonist (EC50s = 23, 48, and 63 nM for M1, M3, and M5, respectively, and >1 µM for M2 and M4); stimulates secretion by salivary glands and is useful in ameliorating xerostomia (dry mouth)
Cayman Chemical 6-FormylpterIn 10mg
An oxidized pterin that binds to one of two active sites on XO, resulting in “hetero-substrate” inhibition at nanomolar concentrations; converted by XO to 6-carboxylpterin and H2O2, acting as an intracellular generator of H2O2 in cells expressing XO
Cayman Chemical 6 8DIfluoro7hydroxy4meth 10mg
A fluorophore; has been conjugated to streptavidin or secondary antibodies for flow cytometry and used to label bacteria for multi-color FISH; has been coupled to peptides to improve electrospray ionization and MS sensitivity in MALDI-TOF MS; displays absorption/emission maxima of 358/455 nm, respectively
Cayman Chemical 17phenl trInor ProstglndI 10mg
A metabolically stable analog of PGF2α and potent FP receptor agonist (Ki = 1.1 nM at the rat FP receptor)
Cayman Chemical Fantofarone 10mg
A calcium channel inhibitor; inhibits the L-type voltage-gated calcium channel in isolated rat aorta (IC50 = 0.61 nM) over α1- and β-adrenergic, muscarinic, and histamine H2 receptors in rat heart homogenates (IC50s = >10, >10, 4, and >10 µM, respectively), and the serotonin receptor subtypes 5-HT1 and 5-HT2, as well as histamine H1 and adenosine A1 receptors, in rat brain homogenates (IC50s = >10, 4, >10, and >10 µM, respectively); inhibits peak calcium current in depolarized and hyperpolarized L-type voltage-gated calcium channels (IC50s = 1.4 and 150 nM, respectively); inhibits potassium chloride- and norepinephrine-induced contractions in isolated rat aorta (IC50s = 5.64 and 96 nM, respectively); enhances recovery of cardiac output during reperfusion of isolated rat hearts at 10 nM; prevents angioplasty-induced vasospasms in the femoral artery in a rabbit model of focal atherosclerosis at 50 UG/kg
Cayman Chemical 15 R-ProstaglndIn F2a 10mg
15(R)-PGF2α is the C-15 epimer of the naturally occurring mammalian autacoid PGF2α. It has only 25% of the potency of PGF2α in hamster antifertility studies, which may be due to reduced affinity for FP receptors. Compared to PGF2α, 15(R)-PGF2α has a binding affinity of 6.7% to ovine luteal cell receptors. Similarly, the binding affinity to rat vascular smooth muscle cells is negligible as compared to PGF2α.
Cayman Chemical trnsOcImen 10mg
A monoterpene; a volatile compound involved in plant-plant signaling and plant defense against pests; emission from L. japonicus plants is induced within 24 hours of spider mite (T. urticae) infestation; conditioning of tomato plants using VOCs from transgenic tobacco plants overexpressing trans-β-ocimene synthase increases production of VOCs, reduces the number of aphids (M. euphorbiae) that settle on the plant and the number of nymphs produced by the aphids that settle, as well as increases the number of landings of the aphid parasitoid A. ervi
Cayman Chemical EchothIophateIodIde 10mg
An AChE inhibitor; is more active at ocular acetylcholinesterases than those isolated from rabbit brain, liver, or blood; reduces intraocular pressure and induces miosis in dogs with normotensive eyes and those with inherited glaucoma following topical administration of a 0.125 or 0.25% w/v solution; induces formation of subcapsular cataracts in cynomolgus monkeys
Cayman Chemical methyl1 cyclohexylmethyl1 10mg
An analog of BB-22 that lacks the quinoline group; intended for forensic and research applications
Cayman Chemical CID-2011756 10mg
An inhibitor of all three PKD isoforms (IC50s = 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively); cell permeable, blocking the phosphorylation of PKD1 on Ser916 (an autocatalytic target) in LNCaP prostate cancer cells in response to phorbol esters (EC50 = 10 μM)
Cayman Chemical ArachIdoyl glycIn 10mg
Consists of arachidic acid with glycine attached at its carboxy terminus